Sitagliptin/Metformin AL, manufactured by Aliud Pharma GmbH (Germany), is a film-coated tablet combining sitagliptin (50 mg), a DPP-4 inhibitor, and metformin hydrochloride (1000 mg), a biguanide. This dual-action therapy improves glycemic control in adults with type 2 diabetes mellitus, particularly when diet and exercise alone are insufficient.
Mechanism of action:
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Sitagliptin: Enhances the body’s own incretin hormones, increasing insulin secretion and decreasing glucagon levels after meals.
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Metformin: Reduces glucose production in the liver, improves insulin sensitivity, and decreases intestinal glucose absorption.
Indications:
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Adults with type 2 diabetes mellitus requiring dual therapy
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As an alternative to separate administration of sitagliptin and metformin
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Often used when monotherapy does not provide adequate glycemic control
Key benefits:
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Convenient single tablet with dual glucose-lowering effect
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Clinically proven to improve HbA1c levels
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Well tolerated when used under medical supervision
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Supports lifestyle interventions (diet and exercise)
⚠️ Important safety information:
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Prescription-only medicine
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Not for use in type 1 diabetes, diabetic ketoacidosis, or severe kidney/liver impairment
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May cause gastrointestinal side effects (nausea, diarrhea) or rare lactic acidosis
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Regular monitoring of kidney function and blood glucose recommended
Form: Film-coated tablets
Pack size: 56 tablets
Manufacturer: Aliud Pharma GmbH, Germany